Question
Clinical Pharmacy and Therapeutics Question on Drug therapy
A neonate suffering from icterus is intravenously administered with phenobarbital. The justification for this therapy is:
A
Phenobarbital is a short acting barbiturate and hence safe to induce sleep in neonates
B
Phenobarbital suppresses the bilirubin synthesis in neonates
C
Phenobarbital suppresses hepatic glucuronyl transferase and increases clearance of bilirubin
D
Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin
Answer
Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin
Explanation
Solution
The correct option is (D): Phenoarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin