Question

Which among the following compounds is obtained as a major product X in reaction given below?

Anisole acetyl chloride $\xrightarrow{AlCl_3 \text{ (anhydrous)}} X$

• A. 2-Methoxy acetophenone
• B. 4-methoxy toluene
• C. 2-methoxy toluene
• D. 4-methoxy acetophenone

Answer 1

Answer: (D)

4-methoxy acetophenone

Answer 2

1. Reaction Type:
   The reaction of anisole with acetyl chloride in the presence of $AlCl_3$ is a Friedel–Crafts acylation.

2. Directing Effects:
   The methoxy (–$OCH_3$) group on anisole is an activating, ortho/para directing substituent. Although both ortho and para positions are activated, steric hindrance at the ortho position makes the para substitution more favorable.

3. Product Formation:
   Therefore, the major product is the para-acylated compound, namely, 4-methoxyacetophenone.

Anisole reacts via Friedel-Crafts acylation with acetyl chloride (activated by $AlCl_3$). The methoxy group directs the electrophile to the para position, forming 4-methoxyacetophenone.