Question

30 years old came with complaints of easy fatigability, exertional dyspnea, and weight loss. She also complains of frequent falls. Physical examination revealed there was a bilateral decrease in vibration sense. Her hemoglobin levels were 8.2g%. She was treated with folate. Her anemia improved but neurological symptoms worsened. Which of the following is the most probable reason for her condition ?

• A. Folate not absorbed
• B. Unmasked pyridoxine deficiency
• C. Deficiency of folate reductase in CNS
• D. Folate therapy caused rapid use of Vit B12 stores aggravating symptoms

Answer 1

Answer: (D)

Folate therapy caused rapid use of Vit B12 stores aggravating symptoms

Answer 2

The correct option is (D): Folate therapy caused rapid use of Vit B12 stores aggravating symptoms.