Question
Gynaecology and Obstetrics Question on Role of Hormones in Initiating Reproductive Function
13 yr old child visit gynaecology OPD with a complaint of not attaining menarche with karyotype 46XX. On examination, clitoromegaly is seen. Which enzyme is most likely to be deficient in the above condition ?
A
21 alpha-hydroxylase
B
11 beta-hydroxylase
C
17 alpha-hydroxylase
D
3 beta-hydroxysteroid dehydrogenase
Answer
21 alpha-hydroxylase
Explanation
Solution
The correct option is (A): 21 alpha-hydroxylase.